Abstract
In his lead article, Cwik derives categories for the upstream mapping of germline genome editing (GGE). Some peer commentators refine specific aspects of his analysis or recommend additional dimensions (Brenna 2020; Akatsuka 2020; Sharma et al. 2020). Our concern, instead, is on the suitability of his methods and the resulting categories for setting an ethical agenda for GGE. We join several peer commentators (de Melo-Mart ın 2020; Evans 2020; Weber et al. 2020; Wrigley and Newson 2020).